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Author s : Andrea L. Tranquilli , Stefano R. DOI : Calcium-Channel Blockers CCBs , or calcium antagonists, are a heterogeneous group of drugs that produce cardiovascular effects by preventing the influx of calcium ions through L-type voltage-dependent calcium channels in specialized electrical system and conduction tissue cells, like myocardial and vascular smooth muscle cells. In recent years, CCBs have found their way in obstetrics and gynecology, especially in the management of hypertensive disorders of pregnancy and preterm labor.

The lack of adequate data had created uncertainty about the safety of CCBs in pregnancy.

Association with Gastrointestinal Hemorrhage

Teratogenicity with these agents has been demonstrated in animals, but no cases of possible human malformation or deformity have been reported. Data from human studies suggest that CCBs may cause a clinically insignificant fall in maternal mean arterial pressure, but have little to no effect on uterine perfusion. In many countries, CCBs remain unlicensed for use in pregnancy and it is unlikely the manufacturers will ever apply for this status to change.

We do believe that this is the situation of CCBs for those critical second- and third-trimester conditions such as Gestational hypertension, Preeclampsia, HELLP syndrome and preterm labor. Keywords: Calcium channel blockers, dihydropyridine, benzodiazepine, phenylalkylamine, pregnancy, safety, teratology, fetus, embryology, hypertension. Abstract: Calcium-Channel Blockers CCBs , or calcium antagonists, are a heterogeneous group of drugs that produce cardiovascular effects by preventing the influx of calcium ions through L-type voltage-dependent calcium channels in specialized electrical system and conduction tissue cells, like myocardial and vascular smooth muscle cells.

Detecting skewness from summary information. Brit Med J ; : Measuring inconsistency in meta-analyses. Brit Med J ; : — Calcium antagonists in mania: a double-blind study of verapamil. Psychiatry Res ; 18 : — Verapamil versus lithium in acute mania. Verapamil and lithium in maintenance therapy of manic patients. J Clin Pharmacol ; 27 : — Verapamil for the treatment of acute mania: a double-blind, placebo-controlled trial. Am J Psych ; : — Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms.

Bipolar Disord ; 10 : — Pal Singh G. A double-blind comparative study of clinical efficacy of verapamil versus lithium in acute mania. Int J Psychiatry Clin Pract ; 12 : — Antimanic effects of the calcium-antagonist D A double-blind placebo-controlled study. Clin Neuropharmacol ; 9 : — Use of calcium antagonists in mania.

Psychoneuroendocrinology ; 11 : — Verapamil in treatment-resistant mania: an open trial. J Clin Psychopharmacol ; 7 : — Open trial of a calcium antagonist, nimodipine, in acute mania. Clin Neuropharmacol ; 13 : — Caillard V. Treatment of mania using a calcium antagonist - preliminary trial.

Neuropsychobiology ; 14 : 23— Effectiveness of the combination verapamil and chlorpromazine in the treatment of severe manic or mixed patients. Prog Neuropsychopharmacol Biol Psychiatry ; 19 : — Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association. Bipolar Disord ; 16 : — Silverstone PH, Birkett L.

Diltiazem as augmentation therapy in patients with treatment-resistant bipolar disorder: a retrospective study. J Psychiatry Neurosci ; 25 : — The use of nifedipine for overcoming the insufficient preventive effect of lithium carbonate in patients with affective and schizoaffective psychoses. Zhurnal Nevrologii i Psikhiatrii imeni SS ; 97 : 35— Verapamil treatment for women with bipolar disorder.

Calcium Channel Blockers

Biol Psychiatry ; 51 : — Verapamil—carbamazepine neurotoxicity. J Clin Psychiatry ; 49 : Neurotoxicity caused by lithium—verapamil synergism. J Clin Pharmacol ; 26 : — Delirium induced by verapamil. Am J Psychiatry ; : Choreoathetosis induced by verapamil and lithium treatment. J Clin Psychopharmacol ; 9 : — Gitlin MJ, Weiss J.

Verapamil as maintenance treatment in bipolar illness: a case report. J Clin Psychopharmacol ; 4 : — Verapamil: a new antimanic drug with potential interactions with lithium. J Clin Psychiatry ; 48 : — Deicken RF. Verapamil treatment of bipolar depression. J Clin Psychopharmacol ; 10 : — Dubovsky SL, Buzan R. The role of calcium channel blockers in the treatment of psychiatric disorders.

CNS Drugs ; 4 : 47— Opie LH. Calcium channel antagonists.

Association with Myocardial Infarction

Part IV: Side effects and contraindications drug interactions and combinations. Cardiovasc Drugs Ther ; 2 : — Chobanian AV. Calcium channel blockers. JAMA ; : — Antihypertensive medications and survival in patients with cancer: a population-based retrospective cohort study. Cancer Epidemiol ; 37 : — Angiotensin-converting enzyme inhibitors, calcium channel blockers, and breast cancer.

Arch Intern Med ; : — A cohort study of antihypertensive medication use and breast cancer among Danish women. Breast Cancer Res Treat ; 97 : — Calcium channel blockers and risk of breast cancer: a meta-analysis of 17 observational studies. Use of calcium channel blockers and risk of suicide: ecological findings confirmed in population based cohort study.

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Risk of suicide among users of calcium channel blockers: population based, nested case-control study. Cardiovascular drugs and the risk of suicide: a nested case-control study. Eur J Clin Pharmacol ; 63 : — Depression associated with nifedipine-induced calcium channel blockade. Interactions between calcium channel blockers and the anticonvulsants carbamazepine and phenytoin.

Neurology ; 41 : — Carbamazepine neurotoxicity precipitated by diltiazem. Role of intracellular calcium signaling in the pathophysiology and pharmacotherapy of bipolar disoder: current status. Clin Neurosci Res ; 4 : — Berridge MJ. Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia. Cell Tissue Res ; : — Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder. Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients.

Transl Psychiatry ; 4 : e Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature ; : 95— Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms. Neuropharmacol ; : — Reprogramming psychiatry: stem cells and bipolar disorder. Nat Genet ; 40 : — Craddock N, Sklar P.

Genetics of bipolar disorder. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet ; 43 : — Rare variants in neuronal excitability genes influence risk for bipolar disorder.

Identification of pathways for bipolar disorder: a meta-analysis. JAMA Psychiatry ; 71 : — Arch Gen Psychiatry ; 67 : — Mol Psychiatry ; 20 : — Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Biological insights from schizophrenia-associated genetic loci.

Nature ; : — Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. Neuron ; 81 : — Genetic analysis of association between calcium signaling and hippocampal activation, memory performance in the young and old, and risk for sporadic Alzheimer disease.

JAMA Psychiatry ; 72 : — The impact of a CACNA1C gene polymorphism on learning and hippocampal formation in healthy individuals: a diffusion tensor imaging study. Neuroimage ; 89 : — Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects.

Neuroimage ; 94 : — Mol Psychiatry ; 18 : — A genome-wide association study of sleep habits and insomnia.

Beta blocker and Ca+ Channel blocker overdose; BB and CCB OD

Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatr Scand ; : — Harvey AG. Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation. The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population.

Physiol Rev ; 94 : — The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential. Pharmacol Rev ; 67 : — Structural and functional differences between l -type calcium channels: crucial issues for future selective targeting. Trends Pharmacol Sci ; 32 : — Berger SM, Bartsch D.

Long-acting calcium antagonists in patients with coronary artery disease: a meta-analysis

The role of l -type voltage-gated calcium channels Cav1. Calcium signaling in dendritic spines. Cold Spring Harb Perspect Biol ; 4 : a Verapamil concentrations in cerebrospinal fluid after oral administration. N Engl J Med.

  • Use and Safety of Calcium Channel Blockers in Obstetrics.
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Spedding M, Middlemiss DN. Trends Pharmacol Sci ; 6 : — Progress in brain penetration evaluation in drug discovery and development. J Pharmacol Exp Ther ; : — Structure—brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.

What pharmacology can tell us

J Med Chem ; 52 : — Scriabine A, van den Kerckhoff W. Pharmacology of nimodipine. A review.